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KMID : 0374019950180020097
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Ewha Medical Journal
1995 Volume.18 No. 2 p.97 ~ p.104
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The Role of the Central Parasympathetic Nervous System in Modulating Glucose Metabolism in Streptozotocin-induced Diabetic Rats
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Abstract
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Insulin controls the levels of blood sugar by inhibiting glucose release from live and by stimulating glucose utilization in muscle and adipose tissues. In addition to its peripheral effects, insulin influences circulating glucose levels by
modulating
glucose production and its metabolism through central nervous system. But it is presently not well known whether the central effect of insulin on plasma glucose is mediated by directly or indirectly through CNS actions. The autonomic nervous
system
exerts a dual control over insulin secretion. The parasympathetic nervous system can augment insulin secretions and the sympathetic nervous system can produce a net impairment of insulin release.
In the present study, we measure the changes of blood glucose and pyruvic acid level to examine the effects of intracisternally injected insulin. Carbachol and scopolamine in streptozotocin(STZ)-induce diabetic rats.
@ES The results are as follows:
@EN 1) Streptozotocin produced significant increase in blood glucose and pyruvic acid concentrations.
2) Intracisternally injected insulin markedly reduced blood glucose and pyruvic acid concentrations in STZ-induced diabetic rats.
3) Intracisternally injected cholinominetics, carbachol, reduced blood glucose and pyruvic acid concentrations in STZ-induced diabetic rats.
4) Intracisternally injected anticholinergics, scopolamine, increased the concentration of the blood glucose and inhibited the conentration of the blood pyruvic acid in STZ-induced diabetic rats in modulating peripheral blood glucose metabolism
and
insulin produces hypoglycemic action via central parasympathetic nervous system.
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KEYWORD
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